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Turk J Gastroenterol. 2013;24(2):117-21.

Decrease in gastric cancer susceptibility by MTHFR C677T polymorphism in Ardabil Province, Iran.

Author information

1
Ardabil University of Medical Sciences, Gastrointestinal Research Center, Ardabil, Islamic Republic of Iran. saied.hosseiniasl@arums.ac.ir

Abstract

BACKGROUND/AIMS:

Gastric cancer, as the fourth most frequent malignancy worldwide, has the highest rate among cancer-related disorders in Ardabil province, located in North-West Iran. Methylene tetrahydrofolate reductase is one of the cancer susceptibility genes with considerable polymorphisms. Methylene tetrahydrofolate reductase C677T leads to a decrease of about 30% in its product activity and is reported to have an effect on cancer susceptibility.

MATERIALS AND METHODS:

Methylene tetrahydrofolate reductase C677T genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism on peripheral blood DNA from 76 gastric cancer patients and 91 healthy controls. The statistical significance was calculated by logistic regression analysis.

RESULTS:

The mean age was 64.2±11.1 and 62.1±9.8 years for cases and controls, respectively. Among tumors, 35.5% were diffuse type and others were intestinal. The frequency of genotypes was 61.8%, 32.9%, and 5.3% among cases and 45.1%, 50.6%, and 4.4% among controls for Ala/Ala, Ala/Val, and Val/Val, respectively. CT heterozygotes had lower susceptibility to gastric cancer (p=0.02). This relationship of significance was detected considering gender and age.

CONCLUSIONS:

It was found that T allele has a protective association with age in the Ardabil province.

PMID:
23934457
[Indexed for MEDLINE]
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