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J Nutr Health Aging. 2013 Jul;17(7):600-4. doi: 10.1007/s12603-013-0043-6.

Garlic intake is an independent predictor of endothelial function in patients with ischemic stroke.

Author information

1
Division of neurology, Department of Medicine, Queen Mary Hospital, The university of Hong Kong, Hong Kong SaR, China.

Abstract

OBJECTIVES:

To investigate the effects of garlic on endothelial function in patients with ischemic stroke (ISS).

DESIGN:

Cross-sectional study.

PARTICIPANTS:

125 Chinese patients with prior ISS due to athero-thrombotic disease were recruited from the outpatient clinics during July 2005 to December 2006.

MEASUREMENTS:

Daily allium vegetable intake (including garlic, onions, Chinese chives and shallots) was ascertained by means of a validated food frequency questionnaire for Chinese and brachial artery flow-mediated dilatation (FMD) was measured using high-resolution ultrasound in all subjects.

RESULTS:

The mean age of the study population was 65.9±11.1 years and 69% were males. Mean allium vegetable intake and garlic intake of the study population was 7.5±12.7g/day and 2.9±8.8g/day respectively. Their mean FMD was 2.6±2.3%. Daily intake of total allium vegetable (r=0.36, P<0.01) and garlic (r=0.34, P<0.01) significantly correlated with FMD. Using the median daily allium intake as cut-off (3.37g/day), patients with a low allium intake <3.37g/day was noted to have a lower FMD compared to those with a normal allium intake (2.1±2.1% versus 3.0±2.4%, P<0.05). After adjusting for confounding factors, multi-variate analysis identified that daily allium vegetable (B=0.05, 95% confidence interval: 0.02, 0.09, P<0.01) and garlic (B=0.07, 95% confidence interval: 0.02, 0.12, P<0.01) intake, but not onions, Chinese chives and shallots were independent predictors for changes in FMD in patients with ISS.

CONCLUSIONS:

Daily garlic intake is an independent predictor of endothelial function in patients with ISS and may play a role in the secondary prevention of atherosclerotic events.

PMID:
23933870
DOI:
10.1007/s12603-013-0043-6
[Indexed for MEDLINE]

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