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Nat Neurosci. 2013 Sep;16(9):1179-81. doi: 10.1038/nn.3493. Epub 2013 Aug 11.

Intracortical multiplication of thalamocortical signals in mouse auditory cortex.

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1
Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Abstract

Cortical processing of sensory information begins with the transformation of thalamically relayed signals. We optogenetically silenced intracortical circuits to isolate thalamic inputs to layer 4 neurons and found that intracortical excitation linearly amplified thalamocortical responses underlying frequency and direction selectivity, with spectral range and tuning preserved, and prolonged the response duration. This signal pre-amplification and prolongation enhanced the salience of thalamocortically relayed information and ensured its robust, faithful and more persistent representation.

PMID:
23933752
PMCID:
PMC3844430
DOI:
10.1038/nn.3493
[Indexed for MEDLINE]
Free PMC Article
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