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Joint Bone Spine. 2014 Mar;81(2):164-8. doi: 10.1016/j.jbspin.2013.07.008. Epub 2013 Aug 9.

Cardiovascular risk assessment according to a national calibrated score risk index in psoriatic arthritis patients without clinically evident cardiovascular disease or classic atherosclerosis risk factors.

Author information

1
Rheumatology Division, Hospital Universitario San Cecilio, Granada, Spain. Electronic address: Jose_rosales37@hotmail.com.
2
Rheumatology Division, Hospital Universitario San Cecilio, Granada, Spain.
3
Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain.

Abstract

OBJECTIVE:

To assess cardiovascular (CV) risk in psoriatic arthritis (PsA) patients without clinically evident CV disease or classic atherosclerosis risk factors according to the SCORE chart following the EULAR recommendations.

METHODS:

Eighty PsA patients without previous CV events or atherosclerosis risk factors and eighty matched controls were included. Information on demographic, anthropometric and clinical-serological data of disease was assessed. The national calibrated Systematic Coronary Risk Evaluation (SCORE) index was calculated and the association between this SCORE and clinical-serological data of these patients was analyzed.

RESULTS:

PsA patients had higher acute phase reactants as well as higher SCORE mean values than healthy controls (1.99±3.52 vs. 1.0±1.74; P=0.028). According to SCORE definitions, 71 (89%) patients had low-intermediate CV risk and 9 (11%) were above the threshold of high risk. In the control group, 76 (95%) had low-intermediate risk and four (5%) had high CV risk. However, there were no differences in CV risk stratification between both groups (P=0.148). PsA patients with high-very high CV risk had longer disease duration (P=0.001) and higher levels of triglycerides (P=0.009). PsA patients showed a significant correlation between SCORE values and disease duration (β=0.185; P=0.0001) and the average annual levels of C reactive protein (CRPa), β=2.38; P=0.014.

CONCLUSION:

CV risk assessment in PsA patients without clinically evident CV disease or classic atherosclerosis risk factors may be underestimated by using only the SCORE chart. In these patients, disease duration and the CRPa may help to establish a better stratification of the actual CV risk.

KEYWORDS:

Cardiovascular events; Cardiovascular risk; EULAR task force recommendations; Psoriatic arthritis; SCORE

PMID:
23932927
DOI:
10.1016/j.jbspin.2013.07.008
[Indexed for MEDLINE]

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