Format

Send to

Choose Destination
J Egypt Natl Canc Inst. 2013 Sep;25(3):151-60. doi: 10.1016/j.jnci.2013.06.001. Epub 2013 Jul 17.

Comparison of abdominoperineal resection and low anterior resection in lower and middle rectal cancer.

Author information

1
Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

INTRODUCTION:

This study aimed to investigate local control and survival rates following abdominoperineal resection (APR) compared with low anterior resection (LAR) in lower and middle rectal cancer.

METHODS:

In this retrospective study, 153 patients with newly histologically proven rectal adenocarcinoma located at low and middle third that were treated between 2004 and 2010 at a tertiary hospital. The tumors were pathologically staged according to the 7th edition of the American Joint Committee on Cancer (AJCC) staging system. Surgery was applied for 138 (90%) of the patients, of which 96 (70%) underwent LAR and 42 were (30%) treated with APR. Total mesorectal excision was performed for all patients. In addition, 125 patients (82%) received concurrent (neoadjuvant, adjuvant or palliative) pelvic chemoradiation, and 134 patients (88%) received neoadjuvant, adjuvant or concurrent chemotherapy. Patients' follow-up ranged from 4 to 156 (median 37) months.

RESULTS:

Of 153 patients, 89 were men and 64 were women with a median age of 57 years. One patient (0.7%) was stage 0, 15 (9.8%) stage I, 63 (41.2%) stage II, 51 (33.3%) stage III and 23 (15%) stage IV. There was a significant difference between LAR and APR in terms of tumor distance from anal verge, disease stage and combined modality therapy used. However, there was no significant difference regarding 5-year local control, disease free and overall survival rates between LAR and APR.

CONCLUSION:

LAR can provide comparable local control, disease free and overall survival rates compared with APR in eligible patients with lower and middle rectal cancer.

KEYWORDS:

Abdominoperineal; Chemoradiation; Local control; Low anterior resection; Rectal cancer; Surgery; Survival

PMID:
23932752
DOI:
10.1016/j.jnci.2013.06.001
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for The Egyptian National Cancer Institute
Loading ...
Support Center