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Leuk Res. 2013 Oct;37(10):1229-32. doi: 10.1016/j.leukres.2013.07.014. Epub 2013 Aug 6.

Multiple myeloma-induced hyperammonemic encephalopathy: an entity associated with high in-patient mortality.

Author information

  • 1Division of Hematology and Oncology, Mayo Clinic, Rochester, MN, USA.

Abstract

Hyperammonemia attributed to multiple myeloma (MM) has been rarely reported. We present 6 patients from our institution and 34 from the literature with MM-induced hyperammonemic encephalopathy. The median age was 67 years with male:female ratio of 1.8:1. The median ammonia level was 114 umol/L. IgG and IgA MM was seen in 40% and 35% of cases, respectively. The in-patient mortality was 48%. The in-patient mortality was 31% in patients who received MM-directed therapy and 100% in those who did not received MM-directed therapy. Hyperammonemic encephalopathy is a rare complication in MM and is associated with high in-patient mortality.

KEYWORDS:

Ammonia; Encephalopathy; Myeloma

PMID:
23932549
DOI:
10.1016/j.leukres.2013.07.014
[PubMed - indexed for MEDLINE]
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