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Am J Hum Genet. 2013 Sep 5;93(3):422-38. doi: 10.1016/j.ajhg.2013.07.006. Epub 2013 Aug 8.

Genetic evidence for recent population mixture in India.

Author information

1
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. moorjani@genetics.med.harvard.edu

Abstract

Most Indian groups descend from a mixture of two genetically divergent populations: Ancestral North Indians (ANI) related to Central Asians, Middle Easterners, Caucasians, and Europeans; and Ancestral South Indians (ASI) not closely related to groups outside the subcontinent. The date of mixture is unknown but has implications for understanding Indian history. We report genome-wide data from 73 groups from the Indian subcontinent and analyze linkage disequilibrium to estimate ANI-ASI mixture dates ranging from about 1,900 to 4,200 years ago. In a subset of groups, 100% of the mixture is consistent with having occurred during this period. These results show that India experienced a demographic transformation several thousand years ago, from a region in which major population mixture was common to one in which mixture even between closely related groups became rare because of a shift to endogamy.

PMID:
23932107
PMCID:
PMC3769933
DOI:
10.1016/j.ajhg.2013.07.006
[Indexed for MEDLINE]
Free PMC Article

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