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Thorac Surg Clin. 2013 Aug;23(3):327-35. doi: 10.1016/j.thorsurg.2013.04.007. Epub 2013 Jun 4.

The role of surgery in patients with clinical n2 disease.

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  • 1Department of Thoracic and Cardiovascular Surgery, MD Anderson Cancer Center, 1400 Pressler, FCT 19.5066, Unit 1489, Houston, TX 77030-4009, USA.


Patients with N2 non-small cell lung carcinoma have ipsilateral mediastinal adenopathy with stage IIIA disease. Most of these patients are still staged solely using imaging techniques, which causes a significant error in staging if not combined with some form of surgical staging of the mediastinum. N2 disease forms a spectrum of disease ranging from occult microscopic disease to bulky multistation adenopathy. Proper understanding of the prognosis and treatment implications for each form of mediastinal lymph node metastases has led to the selective use of surgery to treat these patients. This article reviews the role of surgery in the management of patients with N2 mediastinal involvement.

Copyright © 2013 Elsevier Inc. All rights reserved.


Chemotherapy; Metastatic mediastinal lymph node; Non–small lung carcinoma; Radiation therapy; Surgery

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