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Neuroimaging Clin N Am. 2013 Aug;23(3):527-55. doi: 10.1016/j.nic.2013.03.002. Epub 2013 May 10.

Adult brain tumors: clinical applications of magnetic resonance spectroscopy.

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Clínica Felippe Mattoso, Barra da Tijuca, Rio de Janeiro 30112011, Brazil.


Proton magnetic resonance spectroscopy (H-MRS) may be helpful in suggesting tumor histology and tumor grade and may better define tumor extension and the ideal site for biopsy compared with conventional magnetic resonance (MR) imaging. A multifunctional approach with diffusion-weighted imaging, perfusion-weighted imaging, and permeability maps, along with H-MRS, may enhance the accuracy of the diagnosis and characterization of brain tumors and estimation of therapeutic response. Integration of advanced imaging techniques with conventional MR imaging and the clinical history help to improve the accuracy, sensitivity, and specificity in differentiating tumors and nonneoplastic lesions.


Adult brain tumors; Differential diagnosis; Proton magnetic resonance spectroscopy (H-MRS); Therapeutic response; Tumor extension; Tumor grade; Tumor histology; Tumor progression

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