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Curr Biol. 2013 Aug 5;23(15):R662-5. doi: 10.1016/j.cub.2013.06.054.

Lineage specification: reading the instructions may help!

Author information

1
UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK. g.may@ucl.ac.uk

Abstract

Understanding lineage specification is biologically important and critical for the production of cells for regenerative medicine. Extrinsic cues are clearly necessary but do they direct or select lineage? Single-cell analysis now suggests that cytokine signaling can instruct lineage choice in blood stem cells.

PMID:
23928087
DOI:
10.1016/j.cub.2013.06.054
[Indexed for MEDLINE]
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