Format

Send to

Choose Destination
See comment in PubMed Commons below
Chem Commun (Camb). 2013 Sep 25;49(74):8232-4. doi: 10.1039/c3cc43257b.

Domino Rh-catalyzed hydroformylation-double cyclization of o-amino cinnamyl derivatives: applications to the formal total syntheses of physostigmine and physovenine.

Author information

  • 1Department of Chemistry, National Chung Hsing University, Taichung, 402, Taiwan, ROC. wchiou@dragon.nchu.edu.tw

Abstract

A parallel, versatile and efficient route to synthesis of pyrrolidinoindoline and tetrahydrofuranoindoline alkaloids from cinnamyl derivatives has been developed, featuring a domino Rh-catalyzed hydroformylation-double cyclization sequence. This method can be applied to the syntheses of anti-Alzheimer drugs such as physostigmine and physovenine.

PMID:
23926596
DOI:
10.1039/c3cc43257b
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry
    Loading ...
    Support Center