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Chem Commun (Camb). 2013 Sep 21;49(73):8000-2. doi: 10.1039/c3cc42709a. Epub 2013 Aug 7.

Crosstalk between Cu(I) and Zn(II) homeostasis via Atx1 and cognate domains.

Author information

1
Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

Abstract

The copper metallochaperone Atx1 and the N-terminal metal-binding domain of a copper-transporting ATP-ase can form tight Zn(II)-mediated hetero-complexes in both cyanobacteria and humans. Copper and zinc homeostasis could be linked by metal binding to these CXXC-containing proteins.

PMID:
23926594
PMCID:
PMC3763678
DOI:
10.1039/c3cc42709a
[Indexed for MEDLINE]
Free PMC Article

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