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Exp Biol Med (Maywood). 2013 Sep;238(9):1047-54. doi: 10.1177/1535370213497882. Epub 2013 Aug 7.

Galangin induces human colon cancer cell death via the mitochondrial dysfunction and caspase-dependent pathway.

Author information

1
Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, Busan 633-165, South Korea.

Abstract

Galangin is a member of flavonols and found in Alpinia officinarum, galangal root, and propolis. Previous studies have demonstrated that galangin has anti-cancer effects on several cancers, including melanoma, hepatoma, and leukaemia cells. However, anti-cancer activity of galangin on human colon cancer has not been established yet. In this study, we investigated the anti-cancer effects of galangin on two types of human colon cancer cells (HCT-15 and HT-29). We found that galangin induced apoptosis and DNA condensation of human colon cancer cells in a dose-dependent manner. We also determined that galangin increased the activation of caspase-3 and -9, and release of apoptosis inducing factor from the mitochondria into the cytoplasm by Western blot analysis. In addition, galangin induced human colon cancer cell death through the alteration of mitochondria membrane potential and dysfunction. These results suggest that galangin induces apoptosis of HCT-15 and HT-29 human colon cancer cells and may prove useful in the development of therapeutic agents for human colon cancer.

KEYWORDS:

Human colon cancer; apoptosis; caspase activation; chromatin condensation; galangin

PMID:
23925650
DOI:
10.1177/1535370213497882
[Indexed for MEDLINE]

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