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Org Lett. 2013 Aug 16;15(16):4186-9. doi: 10.1021/ol401891z. Epub 2013 Aug 7.

Spiro fused diterpene-indole alkaloids from a creek-bottom-derived Aspergillus terreus.

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1
Natural Products Discovery Group, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, Oklahoma 73019-5251, USA.

Abstract

Four metabolites, teraspiridoles A-D (2-5), formed from the merger of a diterpene and modified indole scaffold were obtained from an Aspergillus terreus isolate. The structures and absolute configurations of these natural products were established using NMR, mass spectrometry, Marfey's method, VCD, and ECD data. Teraspiridole B (3) exhibited weak inhibition of planaria regeneration/survival.

PMID:
23924243
PMCID:
PMC3786142
DOI:
10.1021/ol401891z
[Indexed for MEDLINE]
Free PMC Article
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