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PLoS One. 2013 Jul 29;8(7):e70823. doi: 10.1371/journal.pone.0070823. Print 2013.

Profiling of circulating microRNAs after a bout of acute resistance exercise in humans.

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1
Faculty of Sport Sciences, Waseda University, Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology/Waseda University, Tokorozawa, Saitama, Japan.

Abstract

Recent studies have revealed a new aspect of physiological regulation in which microRNAs (miRNAs) play fundamental roles in diverse biological and pathological processes. Furthermore, it was recently discovered that miRNAs are stably secreted into blood and that circulating miRNAs may play important roles in cell-cell communication. Here, we examined whether the circulating miRNA profile is affected by acute resistance exercise. Twelve males performed a resistance exercise session (bench press and leg press), consisting of five sets of 10 repetitions at 70% of maximum strength, with a 1 min rest between sets. Blood samples were taken before exercise, and at 0 and 60 min, 1 day, and 3 days after exercise. The circulating miRNA profile was determined by microarray analysis. Quantitative real-time PCR confirmed that the miR-149* level increased three days after resistance exercise. In contrast, the miR-146a and miR-221 levels decreased three days after resistance exercise. Our findings suggest that circulating miRNA levels change in response to acute resistance exercise, and miRNAs may play important roles in resistance-exercise-induced adaptation.

PMID:
23923026
PMCID:
PMC3726615
DOI:
10.1371/journal.pone.0070823
[Indexed for MEDLINE]
Free PMC Article
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