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World J Gastroenterol. 2013 Aug 7;19(29):4671-8. doi: 10.3748/wjg.v19.i29.4671.

Update on small intestinal stem cells.

Author information

1
Department of Internal Medicine and Gastroenterology, Università Cattolica del Sacro Cuore, Rome, Largo A. Gemelli 8, 00197 Rome, Italy. valentina.tesori@libero.it

Abstract

Among somatic stem cells, those residing in the intestine represent a fascinating and poorly explored research field. Particularly, somatic stem cells reside in the small intestine at the level of the crypt base, in a constant balance between self-renewal and differentiation. Aim of the present review is to delve into the mechanisms that regulate the delicate equilibrium through which intestinal stem cells orchestrate intestinal architecture. To this aim, special focus will be addressed to identify the integrating signals from the surrounding niche, supporting a model whereby distinct cell populations facilitate homeostatic vs injury-induced regeneration.

KEYWORDS:

Intestinal regeneration; Intestinal stem cells; Lgr5; Niche; Organoids

PMID:
23922464
PMCID:
PMC3732839
DOI:
10.3748/wjg.v19.i29.4671
[Indexed for MEDLINE]
Free PMC Article

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