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Clin Cancer Res. 2013 Sep 1;19(17):4547-9. doi: 10.1158/1078-0432.CCR-13-1524. Epub 2013 Aug 6.

Acute infection induces a metastatic niche: a double menace for cancer patients.

Author information

1
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.

Abstract

Tumor-derived factors can induce a premetastatic niche, yet little is known about how metastatic microenvironments are influenced by external insults, such as acute infections commonly seen in patients with cancer. New findings reveal increased metastasis to the lung after acute bacterial infection via the CXCR4/ubiquitin axis, suggesting new targets for antimetastasis therapeutics.

PMID:
23922303
PMCID:
PMC3771332
DOI:
10.1158/1078-0432.CCR-13-1524
[Indexed for MEDLINE]
Free PMC Article

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