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Br J Cancer. 2013 Sep 3;109(5):1291-5. doi: 10.1038/bjc.2013.433. Epub 2013 Aug 6.

Tubal ligation in relation to menopausal symptoms and breast cancer risk.

Author information

1
Epidemiology Branch, National Institute of Environmental Health Sciences, PO Box 12233, 111 TW Alexander Drive, MD A3-05, Research Triangle Park, NC 27709, USA. nicholshb@niehs.nih.gov

Abstract

BACKGROUND:

Local inflammation after tubal ligation may affect ovarian function and breast cancer risk.

METHODS:

We analysed tubal ligation, menopausal characteristics, and breast cancer risk in the Sister Study cohort (N=50,884 women).

RESULTS:

Tubal ligation was associated with hot flashes (hazard ratio (HR) 1.09; 95% confidence interval (CI): 1.06-1.12) but not menopausal age (HR 0.99; 95% CI: 0.96-1.02). Tubal ligation did not have an impact on breast cancer overall (HR 0.95; 95% CI: 0.85-1.06), but had a suggested inverse relation with oestrogen receptor+/progesterone receptor+ invasive tumours (HR 0.84; 95% CI: 0.70-1.01), possibly because of subsequent hysterectomy/bilateral oophorectomy.

CONCLUSION:

Tubal ligation does not influence overall breast cancer risk.

PMID:
23922107
PMCID:
PMC3778289
DOI:
10.1038/bjc.2013.433
[Indexed for MEDLINE]
Free PMC Article

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