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Virulence. 2013 Oct 1;4(7):597-603. doi: 10.4161/viru.25906. Epub 2013 Aug 6.

An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes.

Author information

1
Department of Biology; NUI Maynooth; Maynooth, Co. Kildare Ireland.

Abstract

The insect immune response demonstrates a number of structural and functional similarities to the innate immune system of mammals. As a result of these conserved features insects have become popular choices for evaluating the virulence of microbial pathogens or for assessing the efficacy of antimicrobial agents and give results which are comparable to those that can be obtained using mammals. Analysis of the cellular component of the insect and mammalian immune systems demonstrates many similarities. Insect hemocytes recognize pathogens and phagocytose material in a similar manner to neutrophils. The killing of ingested microbes is achieved in both cell types by the production of superoxide and by the release of enzymes in the process of degranulation. Insect hemocytes and mammalian neutrophils are sensitive to the same inhibitors. This review highlights the strong similarities between the phagocytic cells of both groups of animals and demonstrates the potential benefits of using selected insects as in vivo screening systems.

KEYWORDS:

Galleria; hemocytes; immunity; insect; invertebrate immunity; mini-model; neutrophil; vertebrate immunity

PMID:
23921374
PMCID:
PMC3906293
DOI:
10.4161/viru.25906
[Indexed for MEDLINE]
Free PMC Article

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