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Standardized drug and pharmacological class network construction.

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1
Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.

Abstract

Dozens of drug terminologies and resources capture the drug and/or drug class information, ranging from their coverage and adequacy of representation. No transformative ways are available to link them together in a standard way, which hinders data integration and data representation for drug-related clinical and translational studies. In this paper, we introduce our preliminary work for building a standardized drug and drug class network that integrates multiple drug terminological resources, using Anatomical Therapeutic Chemical (ATC) and National Drug File Reference Terminology (NDF-RT) as network backbone, and expanding with RxNorm and Structured Product Label (SPL). The network consists of 39,728 drugs and drug classes. We calculated and compared structure similarity for each drug/drug class pair from ATC and NDF-RT, and analyzed constructed drug class network from chemical structure perspective.

PMID:
23920899
PMCID:
PMC3909176
[Indexed for MEDLINE]
Free PMC Article
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