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Cancer Lett. 2013 Oct 28;340(1):124-33. doi: 10.1016/j.canlet.2013.07.038. Epub 2013 Aug 3.

Immune microenvironment profiles of tumor immune equilibrium and immune escape states of mouse sarcoma.

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Laboratory of Immunology and Inflammation, Research Center of Basic Medical Science, Tianjin Medical Univerity, Tianjin, China; Department of Immunology, Basic Medical College, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin, China; Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China, Tianjin Medical University, Tianjin, China.


Cancer immunoediting consists of three distinct phases: elimination, equilibrium and escape. Here, for the first time, we investigated the immune microenvironment profiles of tumor immune equilibrium and immune escape states in 3'-methylcholanthrene-induced murine sarcoma model. Our study indicates the relative balance of monocytic MDSCs and antitumor immunity cells (especially CTLs, NK cells and γδT cells) may involve in maintaining tumor cells in a state of immune-mediated dormancy. In addition, high percentages of Treg cells and PMN-MDSCs are associated with the tumor immune escape state - mice with progressing sarcomas. In summary, the relative balance of immune effector cells and suppressive populations in the tumor microenvironment may involve in determining the fate of tumors.


Dormant sarcomas; Immune equilibrium; Immune escape; Immune microenvironment; Immunoediting

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