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Bioinformatics. 2013 Oct 1;29(19):2452-9. doi: 10.1093/bioinformatics/btt414. Epub 2013 Aug 5.

MeltDB 2.0-advances of the metabolomics software system.

Author information

1
Biodata Mining Group, CeBiTec, Bielefeld University, Bielefeld, Germany, Computational Genomics, CeBiTec, Bielefeld University, Bielefeld, Germany, Bruker Daltonik GmbH, Bremen, Germany, Proteome and Metabolome Research, Bielefeld University, Bielefeld, Germany and Max Rubner-Institute, Detmold, Germany.

Abstract

MOTIVATION:

The research area metabolomics achieved tremendous popularity and development in the last couple of years. Owing to its unique interdisciplinarity, it requires to combine knowledge from various scientific disciplines. Advances in the high-throughput technology and the consequently growing quality and quantity of data put new demands on applied analytical and computational methods. Exploration of finally generated and analyzed datasets furthermore relies on powerful tools for data mining and visualization.

RESULTS:

To cover and keep up with these requirements, we have created MeltDB 2.0, a next-generation web application addressing storage, sharing, standardization, integration and analysis of metabolomics experiments. New features improve both efficiency and effectivity of the entire processing pipeline of chromatographic raw data from pre-processing to the derivation of new biological knowledge. First, the generation of high-quality metabolic datasets has been vastly simplified. Second, the new statistics tool box allows to investigate these datasets according to a wide spectrum of scientific and explorative questions.

AVAILABILITY:

The system is publicly available at https://meltdb.cebitec.uni-bielefeld.de. A login is required but freely available.

PMID:
23918246
PMCID:
PMC3777109
DOI:
10.1093/bioinformatics/btt414
[Indexed for MEDLINE]
Free PMC Article

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