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Glia. 2013 Oct;61(10):1571-81. doi: 10.1002/glia.22541. Epub 2013 Aug 5.

Communication between neuronal somata and satellite glial cells in sensory ganglia.

Author information

1
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555-1069, USA. LmHuang@utmb.edu

Abstract

Studies of the structural organization and functions of the cell body of a neuron (soma) and its surrounding satellite glial cells (SGCs) in sensory ganglia have led to the realization that SGCs actively participate in the information processing of sensory signals from afferent terminals to the spinal cord. SGCs use a variety ways to communicate with each other and with their enwrapped soma. Changes in this communication under injurious conditions often lead to abnormal pain conditions. "What are the mechanisms underlying the neuronal soma and SGC communication in sensory ganglia?" and "how do tissue or nerve injuries affect the communication?" are the main questions addressed in this review.

KEYWORDS:

cytokine; gap junction; pain; pannexin; purinergic receptor

PMID:
23918214
PMCID:
PMC3758405
DOI:
10.1002/glia.22541
[Indexed for MEDLINE]
Free PMC Article

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