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Mol Psychiatry. 2014 Jul;19(7):848-52. doi: 10.1038/mp.2013.93. Epub 2013 Aug 6.

Identification of differentially expressed microRNAs across the developing human brain.

Author information

1
1] National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA [2] NIH-University of Cambridge Biomedical Scholars Program, Cambridge, UK [3] Baylor College of Medicine MSTP, Houston, TX, USA.
2
National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.

Abstract

We present a spatio-temporal assessment of microRNA (miRNA) expression throughout early human brain development. We assessed the prefrontal cortex, hippocampus and cerebellum of 18 normal human donor brains spanning infancy through adolescence by RNA-seq. We discovered differentially expressed miRNAs and broad miRNA patterns across both temporal and spatial dimensions, and between male and female prefrontal cortex. Putative target genes of the differentially expressed miRNAs were identified, which demonstrated functional enrichment for transcription regulation, synaptogenesis and other basic intracellular processes. Sex-biased miRNAs also targeted genes related to Wnt and transforming growth factor-beta pathways. The differentially expressed miRNA targets were highly enriched for gene sets related to autism, schizophrenia, bipolar disorder and depression, but not neurodegenerative diseases, epilepsy or other adult-onset psychiatric diseases. Our results suggest critical roles for the identified miRNAs in transcriptional networks of the developing human brain and neurodevelopmental disorders.

PMID:
23917947
PMCID:
PMC3840150
DOI:
10.1038/mp.2013.93
[Indexed for MEDLINE]
Free PMC Article
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