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Trends Cell Biol. 2014 Feb;24(2):90-9. doi: 10.1016/j.tcb.2013.07.002. Epub 2013 Aug 1.

Molecular architecture of the mammalian circadian clock.

Author information

1
Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA; Center for Chronobiology, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: cpartch@ucsc.edu.
2
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
3
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Insitute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: joseph.takahashi@utsouthwestern.edu.

Abstract

Circadian clocks coordinate physiology and behavior with the 24h solar day to provide temporal homeostasis with the external environment. The molecular clocks that drive these intrinsic rhythmic changes are based on interlocked transcription/translation feedback loops that integrate with diverse environmental and metabolic stimuli to generate internal 24h timing. In this review we highlight recent advances in our understanding of the core molecular clock and how it utilizes diverse transcriptional and post-transcriptional mechanisms to impart temporal control onto mammalian physiology. Understanding the way in which biological rhythms are generated throughout the body may provide avenues for temporally directed therapeutics to improve health and prevent disease.

KEYWORDS:

circadian; peripheral clock; post-transcription; transcription

PMID:
23916625
PMCID:
PMC3946763
DOI:
10.1016/j.tcb.2013.07.002
[Indexed for MEDLINE]
Free PMC Article

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