Send to

Choose Destination
Z Evid Fortbild Qual Gesundhwes. 2013;107(4-5):302-8. doi: 10.1016/j.zefq.2012.12.003. Epub 2013 Jan 11.

[Pharmacological therapy of temporomandibular joint pain].

[Article in German]

Author information

Poliklinik für Zahnärztliche Prothetik, Westdeutsche Kieferklinik, Heinrich-Heine-Universität Düsseldorf.


Pharmacological interventions in temporomandibular joint (TMJ) pain differ from corresponding therapeutic interventions of jaw muscle (myofascial) pain. An actual systematic literature search lists and evaluates available articles on randomised controlled trials for treatment of arthralgia of the TMJ. On the basis of the few available trial reports, non-steroidal anti-inflammatory drugs (NSAIDs) seem to be effective, but side effects and drug interactions need to be considered. In relation to other therapeutic modalities, the rapidity of the onset of action of NSAIDs seems to be different, and the extension of side effects can be varied or reduced by changing the application route (oral versus topical). Palmitoylethanolamide (PEA) as dietary supplement for special medical purposes can apparently evoke positive therapeutic effects in TMJ arthralgia which need to be analysed in further studies.


Arthralgia; Arthralgie; Kiefergelenkschmerz; Myoarthropathie; Therapieempfehlung; kraniomandibuläre Dysfunktion; medikamentöse Behandlung; pharmacological intervention; temporomandibular disorders; temporomandibular joint pain; therapeutic recommendation

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center