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Epilepsy Res. 2013 Oct;106(3):318-25. doi: 10.1016/j.eplepsyres.2013.07.001. Epub 2013 Jul 31.

EEG characterization of audiogenic seizures in the hamster strain GASH:Sal.

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1
Instituto de Neurociencias de Castilla y León/IBSAL, C/ Pintor Fernando Gallego, n° 1, 37007 Salamanca, Spain; The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Room 2-34, Miami, FL 33136, USA.

Abstract

The study was performed to characterize GASH:SAL audiogenic seizures as true epileptic activity based on electroencephalographic markers acquired with a wireless implanted radiotelemetry system. We analyzed cortical EEG patterns synchronized with video recordings of convulsive behavior of the GASH:Sal hamster following an acoustic stimulus. All GASH:Sal presented archetypal motor symptoms comparable to current animal models of generalized tonic-clonic epilepsy. Seizures consisted of an initial bout of wild running, followed by opisthotonus, tonic-clonic convulsions, tonic limb extension, and terminated in postictal depression. EEG patterns correlated with behavior and displayed phase appropriate spike-wave complexes, low-amplitude desynchronized activity, and high frequency large-amplitude peaks. Our results confirm that electroencephalographic profiles of the audiogenic seizures of the hamster GASH:Sal are parallel to EEG patterns of other animal models of generalized tonic-clonic seizures. Therefore, this animal may serve as an appropriate model for epilepsy research.

KEYWORDS:

Animal model of epilepsy; Electroencephalography; Radiotelemetry recordings; Video-EEG

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