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Nano Lett. 2013 Sep 11;13(9):4294-8. doi: 10.1021/nl402054w. Epub 2013 Aug 9.

In vivo whole animal fluorescence imaging of a microparticle-based oral vaccine containing (CuInSe(x)S(2-x))/ZnS core/shell quantum dots.

Author information

1
Department of Chemical Engineering, Texas Materials Institute, and Center for Nano- and Molecular Science and Technology, The University of Texas at Austin , Austin, Texas 78712, United States.

Abstract

Zinc sulfide-coated copper indium sulfur selenide (CuInSexS2-x/ZnS core/shell) nanocrystals were synthesized with size-tunable red to near-infrared (NIR) fluorescence with high quantum yield (40%) in water. These nanocrystals were tested as an imaging agent to track a microparticle-based oral vaccine administered to mice. Poly(lactic-co-glycolic acid) (PLGA) microparticle-encapsulated CuInSexSe2-x/ZnS quantum dots were orally administered to mice and were found to provide a distinct visible fluorescent marker in the gastrointestinal tract of living mice.

PMID:
23915166
PMCID:
PMC3796198
DOI:
10.1021/nl402054w
[Indexed for MEDLINE]
Free PMC Article

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