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Cancer Invest. 2013 Aug;31(7):494-9. doi: 10.3109/07357907.2013.820319.

The use of salivary protein secretions as an in vivo model to study Mantel cell lymphoma progression and treatment.

Author information

1
Dental Branch, Department of Diagnostic and Biomedical Sciences, University of Texas Health Science Center (UTHSC), Houston, Texas 77054, USA. charles.streckfus@uth.tmc.edu

Abstract

PURPOSE:

The objective of this study was to compare the salivary protein profiles from an individual diagnosed with MCL before, during, and after chemotherapy.

METHODS:

Saliva specimens acquire prior, during, and after chemotherapy. Specimens were analyzed using a LC-MS/MS mass spectrometer.

RESULTS:

The results of the study suggest salivary protein alterations secondary to MCL and that a number of the proteins were changed as a result of chemotherapeutic intervention suggesting that the treatment, from a proteomic perspective, was efficacious. The study suggests that salivary secretions may be used as in vivo model for studying MCL progression and treatment efficacy.

PMID:
23915074
DOI:
10.3109/07357907.2013.820319
[Indexed for MEDLINE]

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