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Cancer Invest. 2013 Aug;31(7):472-9. doi: 10.3109/07357907.2013.820320.

The role of p53 protein and MMP-2 tumor/stromal cells expression on progressive growth of ovarian neoplasms.

Author information

1
Department of Pathomorphology and Oncological Cytology, Wrocław Medical University, Wrocław, Poland. piotr.grelewski@am.wroc.pl

Abstract

The aim of our study was to evaluate p53 gene/protein status and MMP-2 expression in respect to ovarian tumors progress to define the role of these markers in the metastasis of ovarian carcinomas. MMP-2 and p53 alterations were evaluated on 80 malignant, 30 benign ovarian tumors, and 62 metastatic lesions by using HRM method for mutations in p53 gene and by using RT-PCR for mRNA MMP-2 level. Our data indicate that parallel expression of MMP-2 epithelial/stromal cells and p53 may enhance cells invasion and metastasis in ovarian carcinoma.

PMID:
23915071
DOI:
10.3109/07357907.2013.820320
[Indexed for MEDLINE]

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