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J R Stat Soc Ser C Appl Stat. 2013 Mar;62(2):233-250.

Bias correction for the proportional odds logistic regression model with application to a study of surgical complications.

Author information

1
Brigham and Women's Hospital, Boston, MA, U.S.A.

Abstract

The proportional odds logistic regression model is widely used for relating an ordinal outcome to a set of covariates. When the number of outcome categories is relatively large, the sample size is relatively small, and/or certain outcome categories are rare, maximum likelihood can yield biased estimates of the regression parameters. Firth (1993) and Kosmidis and Firth (2009) proposed a procedure to remove the leading term in the asymptotic bias of the maximum likelihood estimator. Their approach is most easily implemented for univariate outcomes. In this paper, we derive a bias correction that exploits the proportionality between Poisson and multinomial likelihoods for multinomial regression models. Specifically, we describe a bias correction for the proportional odds logistic regression model, based on the likelihood from a collection of independent Poisson random variables whose means are constrained to sum to 1, that is straightforward to implement. The proposed method is motivated by a study of predictors of post-operative complications in patients undergoing colon or rectal surgery (Gawande et al., 2007).

KEYWORDS:

Discrete response; Poisson likelihood; multinomial likelihood; multinomial logistic regression; penalized likelihood

PMID:
23913986
PMCID:
PMC3729470

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