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J Gerontol A Biol Sci Med Sci. 2014 Mar;69(3):315-22. doi: 10.1093/gerona/glt109. Epub 2013 Aug 2.

Aging and chronic kidney disease: the impact on physical function and cognition.

Author information

1
MD Division of Nephrology, Stanford University School of Medicine, 777 Welch Road, Suite DE, Room D100, Palo Alto, CA 94304. mktamura@stanford.edu.

Abstract

Evidence has recently been building that the presence of chronic kidney disease (CKD) is an independent contributor to decline in physical and cognitive functions in older adults. CKD affects 45% of persons older than 70 years of age and can double the risk for physical impairment, cognitive dysfunction, and frailty. To increase awareness of this relatively new concept of CKD as a risk factor for accelerated aging, we review studies on the association of CKD with physical function, frailty, and cognitive function. We also present a summary of the proposed mechanisms for these associations.

KEYWORDS:

Chronic kidney disease; Cognitive function.; Frailty; Physical function

PMID:
23913934
PMCID:
PMC4017829
DOI:
10.1093/gerona/glt109
[Indexed for MEDLINE]
Free PMC Article
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