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Methods Mol Biol. 2013;1045:51-70. doi: 10.1007/978-1-62703-541-5_4.

Antibody-drug conjugate payloads.

Author information

1
Heidelberg Pharma GmbH, Ladenburg, Germany.

Abstract

Toxin payloads, or drugs, are the crucial components of therapeutic antibody-drug conjugates (ADCs). This review will give an introduction on the requirements that make a toxic compound suitable to be used in an antitumoral ADC and will summarize the structural and mechanistic features of four drug families that yielded promising results in preclinical and clinical studies.

PMID:
23913141
DOI:
10.1007/978-1-62703-541-5_4
[Indexed for MEDLINE]

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