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Indian J Pediatr. 2014 Sep;81(9):943-5. doi: 10.1007/s12098-013-1112-x. Epub 2013 Aug 4.

Ifosfamide induced renal rickets.

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Department of Pediatrics, Pediatric Endocrinology & Pediatric 1, Christian Medical College Hospital, Vellore, Tamil Nadu, 632004, India.


Ifosfamide is commonly used as a chemotherapeutic agent in children. The authors report a 4-y-old boy who developed proximal renal tubulopathy with florid rickets a year after completion of ifosfamide therapy for Ewing's sarcoma. After initiation of treatment, there was complete healing of rickets and he did not need supplements beyond 18 mo. Growth monitoring and musculoskeletal system examination is important in all children who have received ifosfamide therapy. Routine monitoring for nephrotoxicity during and after ifosfamide therapy helps in early identification and intervention.

[Indexed for MEDLINE]

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