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Mol Immunol. 2013 Dec;56(4):561-2. doi: 10.1016/j.molimm.2013.05.234. Epub 2013 Aug 1.

Not only immunoglobulins, C-reactive protein too.

Author information

1
Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, P.O. Box 70577, Johnson City, TN 37614, USA. Electronic address: agrawal@etsu.edu.

Abstract

The purpose of this letter is to expand a discussion, published recently in Molecular Immunology, on the post-secretion gain of function by immunoglobulins. It was reported that some circulating IgG molecules in all healthy individuals acquire novel antigen-binding specificity after exposure to conditions that change protein conformation, such as acidic pH. Another protein, C-reactive protein, also acquires novel ligand-binding specificity post-secretion after a switch from its native pentameric conformation to non-native pentameric conformation. Thus, that the functions of a protein depend upon its alternate structural states, and therefore on the surrounding milieu, is a more general phenomenon for some ancient molecules of the immune system than previously thought.

KEYWORDS:

C-reactive protein; Immunoglobulins

PMID:
23911413
DOI:
10.1016/j.molimm.2013.05.234
[Indexed for MEDLINE]

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