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Cell. 2013 Aug 1;154(3):490-503. doi: 10.1016/j.cell.2013.07.011.

Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes.

Author information

1
Biochemistry and Biophysics, Genentech Hall 600, 16th Street, University of California, San Francisco, San Francisco, CA 94158, USA. geeta.narlikar@ucsf.edu

Abstract

Chromatin provides both a means to accommodate a large amount of genetic material in a small space and a means to package the same genetic material in different chromatin states. Transitions between chromatin states are enabled by chromatin-remodeling ATPases, which catalyze a diverse range of structural transformations. Biochemical evidence over the last two decades suggests that chromatin-remodeling activities may have emerged by adaptation of ancient DNA translocases to respond to specific features of chromatin. Here, we discuss such evidence and also relate mechanistic insights to our understanding of how chromatin-remodeling enzymes enable different in vivo processes.

PMID:
23911317
PMCID:
PMC3781322
DOI:
10.1016/j.cell.2013.07.011
[Indexed for MEDLINE]
Free PMC Article

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