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Int J Med Inform. 2013 Oct;82(10):987-95. doi: 10.1016/j.ijmedinf.2013.07.001. Epub 2013 Jul 30.

Evaluation of the pilot program on the real-time drug utilization review system in South Korea.

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School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, South Korea.
College of Pharmacy, Chung-Ang University, Seoul, South Korea.
School of Medicine, Catholic University, Seoul, South Korea.
School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, South Korea. Electronic address:



A pilot drug utilization review (DUR) program was initiated by the Korean government, which provided safety information in real-time at the stage of prescribing and dispensing. This study aimed to compare the "physician/pharmacist Co-DUR" system and the traditional "pharmacist-only DUR" system.


Data collected during a DUR pilot program from July 1 to October 31 of 2009 were obtained from the Health Insurance Review & Assessment Service. Descriptive analyses were conducted to investigate DUR-pop up alert rates, categories of alerts, the reasons for dispensing without prescription change after an alert, and changes in drug expenditures associated with the DUR.


DUR pop-up alert rates were 8.55% at clinics and 1.90% at pharmacies in the physician/pharmacist Co-DUR, whereas the rate was 2.22% in the pharmacist-only DUR. Rates of pop-up alerts were high for between-prescription ingredient duplication at pharmacies, whereas for clinics, the rate for drug-pregnancy contraindications was high. A greater reduction in drug expenditure was estimated in the physician/pharmacist Co-DUR compared to the pharmacist-only DUR.


The physician/pharmacist Co-DUR has better sensitivity at detecting potential adverse drug events than the pharmacist-only DUR. Pharmacists also have opportunities to double-check prescribed drugs when doctors do not voluntarily modify pop-up alerts. Further comprehensive study will be needed to confirm the results of pilot program that favored the physician/pharmacist Co-DUR.


Drug utilization review; Expenditures; Inappropriate prescribing; Real-time system

[Indexed for MEDLINE]

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