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Curr Opin Struct Biol. 2013 Oct;23(5):695-703. doi: 10.1016/j.sbi.2013.07.008. Epub 2013 Jul 30.

Fortifying the wall: synthesis, regulation and degradation of bacterial peptidoglycan.

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1
Department of Biochemistry and Molecular Biology and Center for Blood Research, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.

Abstract

Growth and maintenance of the protective peptidoglycan cell wall are vital to bacterial growth and morphogenesis. Thus, the relative rate and spatiotemporal control of the synthesis and degradation of this net-like polymer defines bacterial cell shape. In recent years, our understanding of the processes that govern this delicate metabolic balance has improved and should lend insight into how to therapeutically target the system in the future.

PMID:
23910891
DOI:
10.1016/j.sbi.2013.07.008
[Indexed for MEDLINE]
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