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Clin Exp Rheumatol. 2013 Mar-Apr;31(2 Suppl 76):71-80. Epub 2013 Jul 22.

Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO Registry.

Collaborators (611)

Raffier B, Hirschi M, Trautinger F, Schmidt P, Stetter M, Hundstorfer M, Reinhart V, Monshi B, Pirkhammer D, Richter L, Hamberger N, Metz S, Feldmann R, Semmelweis K, Lackner K, Tomi N, Kolle H, Hafner F, Brodmann M, Kuen-Spiegel M, Minmair G, Heil PM, Broil H, Holzer G, Illmer X, Rintelen B, Sautner J, Takacs M, Thun M, Zemanova I, Soukup T, Smrzova A, Bohmova J, Prochazkova L, Nemec P, Fojtik Z, Suchy D, Becvar R, Olsen AB, Sondergaard KH, Luosu jarvi R, Vidqvist KL, Madaule S, Beneton N, Maillard H, Charlanne H, GranelBrocard F, Hachulla E, Hatron PY, Jourdain N, Lambert M, Launay D, Morell S, Woijtasik G, Skowron F, Zenone T, Dadban A, Lok C, Ferrandiz D, MagyBertrand N, Moiton MP, Taieb A, Balquiere S, Belin E, Droitcourt C, Julien S, Prey S, Boulon C, Constans J, Doutre MS, Kostrzwewa E, Richez C, Greco M, Misery L, Sassolas B, Collet E, Berthier S, Leguy-Seguin V, Imbert B, Carpentier P, Blaise S, Couraud A, Doeffel-Hantz V, Spars A, Bezanahary H, Boussely N, Dumonteil S, Fauchais AL, Goudran G, Loustaud-Ratti V, Manea P, Vidal E, Coppere B, DesmursClavel H, Girard-Madoux MH, Hot A, Ninet J, Granel B, Cohen JD, Keynote A, Khau van Kien A, Le Quellec A, Riviere S, Rullier P, Bessis D, Farcas C, Bravetti V, Moline T, Wahl D, Zuily S, Granel-Brocard F, Agard C, Durant C, Fuzibet JG, Queyrel V, Berezne A, Guillevin L, Mouthon L, Cabane J, Tiev K, Toledano C, Lazareth I, Michon-Pasturel U, Priollet P, Reguiai Z, CazaletsLacoste C, Jego P, Letremy A, Perlat A, Duval-Modeste AB, Chatelus E, Chiffot H, Sibillia J, Sordet C, Adoue D, Couret B, Moulis G, Pugnet G, Sailler L, Diot E, Gaches F, Farge D, Keshtmand H, Frances C, von Elling A, Bora D, Ebel J, Ahmadi-Simab K, Klein E, Hahn K, Schulze K, Rasche C, Riemekasten G, Lee HH, Deuschle K, Mattat K, Becker M, Worm M, Mensing C, Klings D, Mensing H, Messall J, Zuper R, Eilbacher P, Saar P, Kaufmann P, Hallermann C, Schmidt K, Wahn H, Schildt K, Schuart T, Kaczmarczyk A, Kellner C, von Oelhafen J, Baron von Bildering P, Kunze S, Kleiner HJ, Alsheimer B, Schuetz N, Miirker-Hermann E, Gottl KH, Weiss E, Reischel N, Kern S, Goettl KH, GoetheUniversitiitsklinikum JW, Himsel A, Henkemeier U, Schwarting A, Hazenbiller A, Nichelmann V, Rumbaur C, Boesenberg I, Schmeiser T, Mueller-Ladner U, Unholzer A, Starz H, Welzel J, Plaumann K, Stoeckl F, Sperling S, Podda M, Wagner N, Rapprich H, Niedermeier A, Messer G, Sardy M, Bekou V, Dill-MUller D, Wlodarz M, Belloni B, Huettig B, Ziai M, Hein R, Kneitz C, Federow I, Schneider K, Semmler M, Hapke S, Metzler C, Stein T, Enderlein M, Kayser M, Werthmann M, Guenther CU, Neul S, Hellmich B, Loeffler C, Pflugfelder J, Karaenke P, Mueglich C, Tony HP, Marina P, Popp M, Mittag M, Mittag M, Baumann C, Baumann C, Scheib EG, Scheib EG, Brand H, Wilhelm HU, Wilhelm HU, Bohm J, Dyballa J, Boehm J, Taggeselle J, Taggeselle J, LUthke K, Wuerzburg I, LUthke K, Niefanger K, Niefanger K, Mayer L, Drabek J, Harmuth W, Harmuth W, Dietl S, Moritz D, Dietl S, Gause A, Gause A, Gaubitz M, Hallecker A, Gaubitz M, Krupp E, Rumpel H, Moosig F, Frey P, Kahl S, Linke M, Merk B, Bloching HH, Ochs W, Kurthen R, Kurthen R, Eiden E, Guertler I, Aries PM, Kirchberg S, Jahnke K, Mettler S, Toeller S, Zwenger S, Langer HE, Deininger F, Hartmann F, Neeck G, Neek G, Wernitzsch H, Meier L, Herr U, Meier U, Aaig W, Schwarting A, Bruckner L, Sheikh N, Wollenhaupt J, Krog B, Wollersdorfer E, Hall R, Diehm C, Tiggers C, Peters J, Kirschke J, Schroeder JO, Zeuner R, Uhlig S, Barth S, Huegel R, Glaeser R, Schaefer C, Monshausen M, Mengden T, Funkert A, Blank N, Lupaschko S, Voss B, Megahed M, Sadeghlar F, Seidel M, Wasmuth JC, Kreuter A, Vosswinkel J, Pfoehler C, Gerber A, Haust M, Hoff NP, Mota R, Akanay-Diesel S, Homey B, Katzemich A, Erfurt-Berge C, Sticherling M, Beyer C, Distler J, Mitchell A, Freundlieb C, Rushentsova U, Hermanns G, Blaschke S, Fiene M, Wessel C, Norgauer J, Rabe B, Schuster J, Scholz J, Kremer K, Robakidze-Torbahn M, Moinzadeh P, Dohse A, Muhlack A, Schultz L, Schult S, Frambach Y, Kruse S, Kettenbach A, Fell I, Schweda K, Steinbrink K, Podobinska M, Fieri beck G, Schanz S, Pfeiffer C, Hassel R, Herrgott I, Sunderkoetter C, Guenzel J, Athanassiou P, Dimitroulas T, Settas L, Kritikos I, Tsifetaki N, Garyfallos A, Vasilopoulos D, Boura P, Kamali S, Aslanidis S, Vlachoyannopoulos P, Galanopoulo V, Sakkas L, Koutroubas A, Elezoglou T, Galanopoulos N, Grier A, Murray M, O'Rourke M, Del Papa N, Maglione W, Zeni S, Foti R, Benenati A, De Vita S, Ferraccioli G, Grassi W, de Angeli R, Pomponio G, Mussi A, Colonna L, Airo P, Zingarelli S, Scorza R, Serverino A, Puppo F, Negrini S, Roma I, Salsano F, Triolo G, Mazzuca S, Carignola R, Gatti S, Lunardi G, Riccieri V, Salvarani C, Bajocchi G, Varcasia G, Marasini B, Belloll L, Matucci-Cerinic M, de Luca R, Stisi S, Bellissimo S, Fusaro E, Pellerito R, Cozzi F, Rizzo M, Bartoluzzi A, Trotta F, Cantatore F, Corrado A, Ferri C, Colaci M, Malavolta N, Mule R, Galeazzi M, Lapadula G, Mathieu A, Vacca A, Giacomelli R, Cipriani P, Montecucco CM, Codullo V, Bucci R, Battaglia E, Valentini G, Cuomo G, Terlizzi N, Serafino L, Reumatologia UO, Bombardieri S, Della Rossa A, Doveri M, Perricone R, de Mattia M, Pallotta S, Groenendael JH, Seys P, Goekoop RJ, Han KH, Wlarvens M, Bonte-Mineur F, de Bois MH, de Beus WM, van Zeben D, Vonk M, Knaapen HK, Smit A, Bootsma H, Ton E, Voskuyl A, Dutmer EA, Stalk JN, Madland TM, Seip M, Hoffmann Vold AM, Bitter H, Stocklund Thomsen R, Resende C, Ponte C, Martinho S, Silva F, Ferreira P, Grilo A, Riso N, Santos C, Camara I, Costa J, Alves J, Oliveira S, Almeida I, Silva I, Cordeiro A, Coelho P, Lukac J, Dolnicar AS, Espinosa G, Mejia JC, Ramos M, Plasin Rodriguez MA, Mera A, Blanco JS, Diaz JJ, Losada L, Perez E, Maneiro JR, Caamano M, Fermindez S, Insua SA, Barbado J, Fonseca EM, Nufio FJ, Castellvi I, Garcia de Ia Pena P, Bellido D, Paulino M, Garcia PV, Salas V, Minguez MD, Sanchez MA, Urrego C, Martin I, Rueda A, Calvo J, Ripoll MM, Torres MC, Corteguera M, Maceiras F, Cruz J, Mosquera JA, Gomez R, Area B, Carrio I, Rubio M, Castellvi Barranco I, Santos P, Simeon CP, Fonollosa V, Egurbide MV, Garcia de Vicuna R, Vicente E, Villaverde V, Fernandez C, Garcia E, Uson J, Miguelez R, Callejas JL, Ortego N, Roman J, Alegre-Sancho JJ, Robles A, Rios JJ, Bonilla MG, Sanchez Andrade A, Vazquez TR, Miranda JA, Saez L, Zea A, De la Puente C, Martinez FG, Aguirre MA, Collado P, Cruz A, Crespo M, Sanchez-Roman J, Castillo MJ, Garcia AM, Muniz G, Hedin PJ, Stahl C, Bracin T, Nordin A, Albertsson K, Rydvald Y, Thorsson C, Hermansson E, Maurer B, Verner D, Schmidt Bosshard R, Hall F, Murphy K, Lamb J, Anderson M, Moots R, Buch M, Bissell L, Madhok R, Hampson R, D'Cruz D, Choong LM, Gordon P, Dobson J, Salerno R, Nisar M, Williams C, Wilcox L, Denton C, Ochiel R, Ngcozana T, Parker L, Vincent R, McHugh N, Cole S, Brown S, James J, Herrick A, Manning J, Moore T, Faizal A, Skyes H, Smythe A, Hamilton A.

Abstract

OBJECTIVES:

Digital ulcers (DUs) are frequent manifestations of systemic scleroderma (SSc). This study assessed functional limitations due to DUs among patients enrolled in the Digital Ulcer Outcome (DUO) Registry, an international, multicentre, observational registry of SSc patients with DU disease.

METHODS:

Patients completed at enrolment a DU-specific functional assessment questionnaire with a 1-month recall period, measuring impairment in work and daily activities, and hours of help needed from others. Physician-reported clinical parameters were used to describe the population. For patients who completed at least part of the questionnaire, descriptive analyses were performed for overall results, and stratified by number of DUs at enrolment.

RESULTS:

This study included 2327 patients who completed at least part of the questionnaire. For patients with 0, 1-2, and ≥3 DUs at enrolment, mean overall work impairment during the prior month among employed/self-employed patients was 28%, 42%, and 48%, respectively. Across all included patients, ability to perform daily activities was impaired on average by 35%, 54%, and 63%, respectively. Patients required a mean of 2.0, 8.7, and 8.8 hours of paid help and 17.0, 35.9, and 63.7 hours of unpaid help, respectively, due to DUs in the prior month. Patients with DUs had more complications and medication use than patients with no DUs.

CONCLUSIONS:

With increasing number of DUs, SSc patients reported more impairment in work and daily activities and required more support from others.

PMID:
23910613
[Indexed for MEDLINE]
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