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Otolaryngol Clin North Am. 2013 Aug;46(4):629-43. doi: 10.1016/j.otc.2013.04.004. Epub 2013 Jun 19.

Advances in radiation oncology for the management of oropharyngeal tumors.

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Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Unit 97, 1515 Holcombe Boulevard, Houston, TX 77030, USA.


The major benefits of modern radiation therapy (eg, intensity-modulated [x-ray] radiation therapy [IMRT]) for oropharyngeal cancer are reduced xerostomia and better quality of life. Intensity-modulated proton therapy may provide additional advantages over IMRT by reducing radiation beam-path toxicities. Several acute and late treatment-related toxicities and symptom constellations must be kept in mind when designing and comparing future treatment strategies, particularly because currently most patients with oropharyngeal carcinoma present with human papillomavirus-positive disease and are expected to have a high probability of long-term survival after treatment.


Head and neck cancer; Intensity-modulated proton therapy; Intensity-modulated radiation therapy; Oropharyngeal tumors; Radiation therapy

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