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Otolaryngol Clin North Am. 2013 Aug;46(4):579-97. doi: 10.1016/j.otc.2013.04.010. Epub 2013 May 25.

Oral premalignancy: the roles of early detection and chemoprevention.

Author information

1
Department of Maxillofacial Surgery, Pitié-Salpêtrière Hospital, 47-83 boulevard de l' Hôpital, Paris 75013, France.

Abstract

Premalignancy and chemoprevention studies in head and neck cancer typically focus on the oral cavity. Avoiding or cessation of alcohol and smoking, early detection of potentially malignant disorders or cancer, and early detection of recurrent and/or second primary tumor form the basis of prevention of oral cancer. Analysis of tissue prospectively collected in evaluation of retinoids for chemoprevention trials allowed identification of molecular biomarkers of risk to develop oral cancer, loss of heterozygosity being the most validated one. Improving risk assessment and identification of new targets for chemoprevention represent the main challenges in this field.

KEYWORDS:

Biomarkers of risk; Chemoprevention; Head and neck cancer; Head and neck squamous cell carcinoma; Loss of heterozygocity; Oral squamous cell carcinoma; Potentially malignant disorder

PMID:
23910471
PMCID:
PMC3734384
DOI:
10.1016/j.otc.2013.04.010
[Indexed for MEDLINE]
Free PMC Article

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