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Otolaryngol Clin North Am. 2013 Aug;46(4):545-66. doi: 10.1016/j.otc.2013.04.001. Epub 2013 Jun 17.

Oral cavity and oropharyngeal squamous cell carcinoma genomics.

Author information

1
Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA.

Abstract

Recent technological advances now permit the study of the entire cancer genome, which can elucidate complex pathway interactions that are not apparent at the level of single genes. In this review, the authors describe innovations that have allowed for whole-exome/genome analysis of genetic and epigenetic alterations and of changes in gene expression. Studies using next-generation sequencing, array comparative genomic hybridization, methylation arrays, and gene expression profiling are reviewed, with a particular focus on findings from recent whole-exome sequencing projects. A discussion of the implications of these data on treatment and future goals for cancer genomics is included.

KEYWORDS:

Genomics; Head and neck squamous cell carcinoma; Oral cavity; Oropharyngeal squamous cell carcinoma

PMID:
23910469
PMCID:
PMC3734385
DOI:
10.1016/j.otc.2013.04.001
[Indexed for MEDLINE]
Free PMC Article
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