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Cell Stem Cell. 2013 Aug 1;13(2):139-40. doi: 10.1016/j.stem.2013.07.014.

Transplantable liver organoids made from only three ingredients.

Author information

1
Department of Surgery, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Liver Center, University of California, San Francisco, San Francisco, CA 94143, USA. willenbringh@stemcell.ucsf.edu

Abstract

Liver cell therapies using induced pluripotent stem cells (iPSCs) are in development. A recent paper in Nature by Takebe et al. expands the range of liver diseases that could be treated with iPSC-derived hepatocytes by combining them with endothelial and stromal cells to generate organoids that survive and function extrahepatically.

PMID:
23910079
PMCID:
PMC3828077
DOI:
10.1016/j.stem.2013.07.014
[Indexed for MEDLINE]
Free PMC Article

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