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Korean J Ophthalmol. 2013 Aug;27(4):299-303. doi: 10.3341/kjo.2013.27.4.299. Epub 2013 Jul 18.

Regression of iris neovascularization after subconjunctival injection of bevacizumab.

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1
Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.

Abstract

To describe three cases of neovascular glaucoma (NVG) where iris or angle neovascularization regressed remarkably after subconjunctival bevacizumab injections used as the initial treatment before pan retinal photocoagulation (PRP) and/or filtering surgery. Three consecutive NVG patients whose intraocular pressure (IOP) was not controlled with maximal medication were offered an off-label subconjunctival injection of bevacizumab (2.5-3.75 mg/0.1-0.15 mL, Avastin). Bevacizumab was injected into the subconjunctival space close to the corneal limbus in two or three quadrants using a 26-gauge needle. Serial anterior segment photographs were taken before and after the injection. Following subconjunctival injection of bevacizumab, iris or angle neovascularization regressed rapidly within several days. Such regression was accompanied by lowering of IOP in all three cases. The patients underwent subsequent PRP and/or filtering surgery, and the IOP was further stabilized. Our cases demonstrate that subconjunctival bevacizumab injection can be potentially useful as an initial treatment in NVG patients before laser or surgical treatment.

KEYWORDS:

Bevacizumab; Neovascular glaucoma; Subconjunctival injection

PMID:
23908579
PMCID:
PMC3730075
DOI:
10.3341/kjo.2013.27.4.299
[Indexed for MEDLINE]
Free PMC Article
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