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J Infect Dis. 2013 Nov 1;208(9):1448-53. doi: 10.1093/infdis/jit340. Epub 2013 Aug 1.

Profile of leukocyte-endothelial cell interactions induced in venules and arterioles by nucleoside reverse-transcriptase inhibitors in vivo.

Author information

1
Departamento de Farmacología and CIBERehd, Facultad de Medicina, Universidad de Valencia.

Abstract

BACKGROUND:

There is controversy regarding cardiovascular (CV) toxicity of the nucleoside reverse-transcriptase inhibitors used to treat human immunodeficiency virus infection.

METHODS:

We evaluated the effects of nucleoside reverse-transcriptase inhibitors on leukocyte-endothelium interactions, a hallmark of CV diseases, in rat mesenteric vessels using intravital microscopy and in human arterial cells using a flow chamber system.

RESULTS:

Abacavir and didanosine increased rolling, adhesion and emigration in rat vessels. These effects were reversed with antibodies against Macrophage-1 antigen (Mac-1) or intercellular adhesion molecule 1 and were reproduced in human cells. Lamivudine, zidovudine, emtricitabine, and tenofovir had no effects.

CONCLUSIONS:

Our results support the association of abacavir and didanosine with CV diseases.

KEYWORDS:

Abacavir; cardiovascular diseases; didanosine; emtricitabine; lamivudine; leukocyte-endothelium interations; tenofovir; zidovudine

PMID:
23908487
DOI:
10.1093/infdis/jit340
[Indexed for MEDLINE]

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