Format

Send to

Choose Destination
See comment in PubMed Commons below
J Int Med Res. 2013 Oct;41(5):1426-36. doi: 10.1177/0300060513493692. Epub 2013 Aug 1.

Meta-analysis of probiotics and/or prebiotics for the prevention of eczema.

Author information

1
Neonatal Department, The First Hospital of Jilin University, Changchun, China.

Abstract

OBJECTIVE:

The efficacy of probiotics and/or prebiotics for preventing eczema in infants remains unclear. This meta-analysis evaluated published studies on pro/prebiotics for eczema prevention, investigating bacterial strain efficacy and changes to the allergy status of the children involved.

METHODS:

Randomized, double-blind, placebo-controlled trials were analysed, irrespective of bacterial strains used in the pro/prebiotics. Studies of pregnant women, nursing mothers and infants receiving pro/prebiotics were included. All infant participants were assessed within 2 years of birth. Incidences of eczema and systemic sensitization were measured by weighted relative risk ratios (RRR).

RESULTS:

The 14 studies on probiotics had a pooled RRR of 0.69 (95% confidence interval [CI]: 0.62, 0.78). Three studies on prebiotic consumption showed a RRR of 0.80 (95% CI: 0.54, 1.18). One study of mixed pro/prebiotic (synbiotic) strains found a RRR ratio of 0.81 (95% CI: 0.66, 0.99). No consistent sensitization changes were found. Only the combination of nonspore lactobacilli and bifidobacteria reduced the incidence of eczema.

CONCLUSION:

This meta-analysis found that probiotics or synbiotics may reduce the incidence of eczema in infants aged <2 years. Systemic sensitization did not change following probiotic administration.

KEYWORDS:

Eczema prevention; infant immune system; meta-analysis; prebiotic; probiotic; synbiotic

PMID:
23908398
DOI:
10.1177/0300060513493692
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center