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Genetics. 2013 Aug;194(4):817-46. doi: 10.1534/genetics.112.145276.

The composition, functions, and regulation of the budding yeast kinetochore.

Author information

1
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Abstract

The propagation of all organisms depends on the accurate and orderly segregation of chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding model organism to identify the components and underlying mechanisms that regulate chromosome segregation. This review focuses on the kinetochore, the macromolecular protein complex that assembles on centromeric chromatin and maintains persistent load-bearing attachments to the dynamic tips of spindle microtubules. The kinetochore also serves as a regulatory hub for the spindle checkpoint, ensuring that cell cycle progression is coupled to the achievement of proper microtubule-kinetochore attachments. Progress in understanding the composition and overall architecture of the kinetochore, as well as its properties in making and regulating microtubule attachments and the spindle checkpoint, is discussed.

KEYWORDS:

biorientation; budding yeast; kinetochore; microtubules; spindle checkpoint

PMID:
23908374
PMCID:
PMC3730914
DOI:
10.1534/genetics.112.145276
[Indexed for MEDLINE]
Free PMC Article
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