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Nat Cell Biol. 2013 Aug;15(8):885-7. doi: 10.1038/ncb2817.

Linking HSCs to their youth.

Erratum in

  • Nat Cell Biol. 2013 Sep;15(9):1131.

Abstract

Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated to boost the lower self-renewal activity of quiescent adult HSCs.

PMID:
23907190
DOI:
10.1038/ncb2817
[Indexed for MEDLINE]
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