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AAPS J. 2013 Oct;15(4):1064-71. doi: 10.1208/s12248-013-9513-3. Epub 2013 Aug 1.

Epigenetic cancer prevention mechanisms in skin cancer.

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1
Departments of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, Baltimore, Maryland, 21201, USA.

Abstract

Epigenetics is an important emerging area for study of mechanisms of cancer prevention. In recent years, it has been realized that cancer prevention agents, derived from natural dietary sources, impact cancer cell survival by modulating epigenetic processes. In the present manuscript, we review key epigenetic regulatory mechanisms and examine the impact of sulforaphane and green tea polyphenols on these processes. We also discuss available information on the epigenetics in the context of skin cancer. These studies indicate that diet-derived chemopreventive agents modulate DNA methylation status and histone modification via multiple processes and point to additional areas for study of epigenetic mechanisms in skin cancer.

PMID:
23904153
PMCID:
PMC3787232
DOI:
10.1208/s12248-013-9513-3
[Indexed for MEDLINE]
Free PMC Article
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