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J Muscle Res Cell Motil. 2013 Aug;34(3-4):261-74. doi: 10.1007/s10974-013-9355-8. Epub 2013 Aug 1.

Cytoskeletal tropomyosins: choreographers of actin filament functional diversity.

Author information

1
Oncology Research Unit, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.

Abstract

The actin cytoskeleton plays a central role in many essential cellular processes. Its involvement requires actin filaments to form multiple populations with different structural and therefore functional properties in specific subcellular locations. This diversity is facilitated through the interaction between actin and a number of actin binding proteins. One family of proteins, the tropomyosins, are absolutely essential in regulating actin's ability to form such diverse structures. In this review we integrate studies from different organisms and cell types in an attempt to provide a unifying view of tropomyosin dependent regulation of the actin cytoskeleton.

PMID:
23904035
PMCID:
PMC3843815
DOI:
10.1007/s10974-013-9355-8
[Indexed for MEDLINE]
Free PMC Article

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